Fall of Tenochtitlan (Spanish Empire & Confederacy of Tlaxcala & Tetzcoco & Otomis & Chalco & Mixquic & Huejotzingo & Iztapalapa vs Triple Alliance & Tenochtitlan & Tlatelolco) took place in 1521 AD during the Spanish conquest of the Aztec Empire.
Wikipedia article on Fall of Tenochtitlan · Wikidata entry
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